![]() He also maintains a long-standing interest in the impact of chronic viral infection on this process, and on the consequences of this on the DNA damage response during carcinogenesis.įor more details, please visit his lab page. ![]() He is also interested in elucidating how deficiencies in these pathways contribute to human disease. He is particularly interested in elucidating how protein Lysine methylation contributes to safeguarding genome stability, and in identifying novel factors involved in this response. Martin’s current research focuses around identifying how cells respond to and resolve DNA damage, particularly that arising during DNA replication. He has published papers in top journals, such as Molecular Cell, Oncogene, Cancer Research and Nature Genetics, and has been invited to speak at both national and international conferences. He also maintains a long-standing interest in the impact of chronic viral infection on lysine methylation and DNA repair, and on the consequences during tumourigenesis. He has particular interests in studying neurodevelopmental disorders caused by mutations in the lysine methylation apparatus. In addition, part of his work focuses on the role of lysine methylation in ensuring human development and preventing rare human diseases. Martin’s area of expertise is the study of a single post-translational modification, known as Lysine methylation, and how this regulates the cellular response to DNA damage. He is also Deputy Director for the Centre for Rare Disease Studies (CRDS) Birmingham. He is currently Associate Professor for Genomics and Rare Disease, and leads a research group working on the cellular response to genotoxic stress. Martin Higgs is a group leader in the Institute of Cancer and Genomic Sciences. ![]()
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